In this study, we employed unbiased lipidomic and transcriptomic approaches to investigate the contribution of IRE1α signalling to lipid metabolism in TNBC. This system biology framework enables the ...

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In nature, many animals respond to cold by entering hibernation, while in clinical settings, controlled cooling is used in transplantation and emergency medicine. However, the molecular mechanisms ...

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. One way cells control the speed and ...

This site displays a prototype of a “Web 2.0” version of the daily Federal Register. It is not an official legal edition of the Federal Register, and does not replace the official print version or the ...

Background: Reactive oxygen species (ROS) function as signaling molecules to regulate reparative macrophage polarization essential for ischemia-induced neovascularization and regeneration of skeletal ...

Intracerebral Hemorrhage (ICH) is a destructive neurovascular disease with no efficient treatment. Trapped Red Blood Cells (RBCs) in the brain lyse releasing toxic heme from hemoglobin. Heme, a ...

A recent publication in Cell demonstrates that arginine, an amino acid that facilitates various cellular processes, including cellular growth, also promotes tumor growth. The study shows that arginine ...

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Signaling rewiring allows tumors survive therapy. Here we show that the decrease of the master regulator microphthalmia transcription factor (MITF) in lethal prostate cancer (PCa) unleashes eukaryotic ...